In March 2022, at the resumed fifth meeting of the United Nations Environment Assembly, UN Member States adopted the historic decision to start negotiating a global treaty to combat plastic pollution. As national delegations and relevant stakeholders in Asia start preparing for the upcoming negotiations, this report aims to provide an analysis of the region’s opportunities to end single-use plastics (SUPs) pollution through the development of this new global treaty. SUPs are of particular interest in this regard, as they are the plastic type that is the most often produced and littered. Moreover, SUPs are used only very briefly, often only once, despite being made of a material that was invented to last. And SUPs are usually very difficult to recycle.